THE CYTOSKELETON

67870 hits after a search on 'cytoskeleton' in PubMed on 05.07.2007 but it can be that simple:

cy`to`skel´e`ton Pronunciation: sī`tô`skĕl´ĭ`t'n

Noun

cytoskeleton - a microscopic network of actin filaments, intermediate filaments and microtubules in the cytoplasm of many living cells that gives the cell shape and coherence

Image by Alexey Khodjakov Nature 408, 423 (2000)

ORGANIZATION

Lectures are held every Thursday, 08:15-11:00 in room AI 1142

Teachers: Boris Hinz, MER PhD and Sophie Clément, PhD (Intermediate Filaments)

Date	No.	Topic	Lecture	Students
20.09.07	01	Introduction Cytoskeleton	3x45'
11.10.07	02	Actin (G to F), isoforms	3x45'
18.10.07	03	Actin (F-actin ABP's)	3x45'
25.10.07	04	Myosin	3x45'
01.11.07	05	Intermediate Filaments	2x60'
08.11.07	06	Microtubules	2x50'	group 1
15.11.07	07	Cell-Cell Junctions	2x50'	group 2
22.11.07	08	Extracellular Matrix	2x50'	group 3
29.11.07	09	Cell-Matrix Junctions	2x35'	group 4
06.12.07	10	Signal Transduction	2x35'	group 5
13.12.07	11	Cell Motility	2x50'	group 6
20.12.07	12	Development	2x50'	group 7
10.01.08	13	Tissue Repair	2x50'	group 8
17.01.08	14	Pathology	2x50'

· Prerequisite for the course is a strong interest in Biology.

· Sessions 01-06 will give an introduction on the basics filament systems comprising the cytoskeleton.

· Sessions 05-14 will start with a lecture on the subject, followed by a student presentation of 25 min + 10 min discussion.

· Presentation will be cut after 25 min (no mercy).

· A list of publications is available for selection by clicking here or on the link 'papers to download' on this page.

· All participants have to prepare questions for the presented paper (and thus to read it!). To check, which paper will be presented, click on the respective course theme image and download from 'Paper PDF'.

· Lecture slides and student's presentations are available after each session on the web-page as PDF. To get presentations, click on the respective session theme image and download from 'Session PDF'.

REFERENCES

References are listed by session on the respective page - follow the course theme image link. For the introduction session and for general preparation, I advise to consulting the respective chapters in a good textbook, such as:

Alberts et al., 'Molecular Biology of the Cell', 4^th edition, Garland Publishing.

Lodish et al., Molecular Cell Biology, 5th edition, W.H Freeman & Co.

REFERENCES INTRODUCTION (not found in any other session)

Amos, L.A., F. van den Ent, and J. Lowe. 2004. Structural/functional homology between the bacterial and eukaryotic cytoskeletons. Curr Opin Cell Biol. 16:24-31.

Carballido-Lopez, R., and J. Errington. 2003. A dynamic bacterial cytoskeleton. Trends Cell Biol. 13:577-83.

Errington, J. 2003. Dynamic proteins and a cytoskeleton in bacteria. Nat Cell Biol. 5:175-8.

Frixione, E. 2000. Recurring views on the structure and function of the cytoskeleton: a 300-year epic. Cell Motil Cytoskeleton. 46:73-94.

Lowe, J., F. van den Ent, and L.A. Amos. 2004. Molecules of the bacterial cytoskeleton. Annu Rev Biophys Biomol Struct. 33:177-98.

Session PDF